Best Bets for NCAA Basketball Picks Against the Spread for Saturday, February 22

Published 8:17 pm Friday, February 21, 2025

The outings on the Saturday college basketball slate for which we have recommended picks against the spread include the Iowa State Cyclones squaring off against the Houston Cougars at Fertitta Center.

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Today’s NCAA Men’s Basketball Picks ATS

ATS Pick: Iowa State +12.5 vs. Houston

Matchup: Iowa State Cyclones at Houston Cougars
Time: 2 p.m. ET
Date: February 22
Computer Projection: Houston by 6.7 points (Bet now on BetMGM)
Spread: Houston (-12.5)
TV Channel: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: Cal Baptist +9.5 vs. Grand Canyon

Matchup: Cal Baptist Lancers at Grand Canyon Antelopes
Time: 8 p.m. ET
Date: February 22
Computer Projection: Grand Canyon by 5.6 points (Bet now on BetMGM)
Spread: Grand Canyon (-9.5)
TV Channel: ESPN+
Live Stream: Watch this game on ESPN+

ATS Pick: Ole Miss +1.5 vs. Vanderbilt

Matchup: Ole Miss Rebels at Vanderbilt Commodores
Time: 3:30 p.m. ET
Date: February 22
Computer Projection: Ole Miss by 2.2 points (Bet now on BetMGM)
Spread: Vanderbilt (-1.5)
TV Channel: SEC Network
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: TCU +7.5 vs. Cincinnati

Matchup: TCU Horned Frogs at Cincinnati Bearcats
Time: 12 p.m. ET
Date: February 22
Computer Projection: Cincinnati by 3.9 points (Bet now on BetMGM)
Spread: Cincinnati (-7.5)
TV Channel: ESPN2
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: Kentucky +9.5 vs. Alabama

Matchup: Kentucky Wildcats at Alabama Crimson Tide
Time: 6 p.m. ET
Date: February 22
Computer Projection: Alabama by 5.9 points (Bet now on BetMGM)
Spread: Alabama (-9.5)
TV Channel: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Bet on this or any men’s college basketball matchup at BetMGM.

ATS Pick: West Virginia +11.5 vs. Texas Tech

Matchup: West Virginia Mountaineers at Texas Tech Red Raiders
Time: 1 p.m. ET
Date: February 22
Computer Projection: Texas Tech by 8.1 points (Bet now on BetMGM)
Spread: Texas Tech (-11.5)
TV Channel: ESPN+
Live Stream: Watch this game on ESPN+

ATS Pick: McNeese -10.5 vs. Texas A&M-CC

Matchup: Texas A&M-CC Islanders at McNeese Cowboys
Time: 5 p.m. ET
Date: February 22
Computer Projection: McNeese by 13.9 points (Bet now on BetMGM)
Spread: McNeese (-10.5)
TV Channel: ESPN+
Live Stream: Watch this game on ESPN+

ATS Pick: Tennessee +1.5 vs. Texas A&M

Matchup: Tennessee Volunteers at Texas A&M Aggies
Time: 12 p.m. ET
Date: February 22
Computer Projection: Tennessee by 1.1 points (Bet now on BetMGM)
Spread: Texas A&M (-1.5)
TV Channel: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

ATS Pick: Appalachian State -3.5 vs. Marshall

Matchup: Marshall Thundering Herd at Appalachian State Mountaineers
Time: 1 p.m. ET
Date: February 22
Computer Projection: Appalachian State by 6.1 points (Bet now on BetMGM)
Spread: Appalachian State (-3.5)
TV Channel: ESPN+
Live Stream: Watch this game on ESPN+

ATS Pick: BYU +7.5 vs. Arizona

Matchup: BYU Cougars at Arizona Wildcats
Time: 10 p.m. ET
Date: February 22
Computer Projection: Arizona by 4.9 points (Bet now on BetMGM)
Spread: Arizona (-7.5)
TV Channel: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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