MSU researchers pioneer new method to detect Chronic Wasting Disease

Published 1:36 pm Thursday, November 2, 2023

Mississippi State University researchers are pioneering a new way to detect the local presence of chronic wasting disease (CWD), a fatal disease threatening the nation’s deer populations.

Steve Demarais, Taylor Chair in Applied Big Game Research and Instruction in MSU’s Forest and Wildlife Research Center, leads a team studying how scrapes left by deer could be a game changer in detecting CWD before noticeable physical symptoms surface.

Scrapes are social cues bucks use to alert other deer of their presence, such as chewing an overhanging branch leaving saliva and pawing the ground to expose soil and urinating in the pawed area.

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Since the state’s first case of CWD was reported in 2018, MSU Deer Ecology and Management Laboratory scientists have been at the forefront of CWD research, addressing the needs of wildlife agencies combating this disease. One of the key needs is to know where the disease is located as early as possible.

“As bucks chew on overhanging branches and urinate on the scrape, prions—abnormally formed proteins—are released if a deer is CWD positive,” Demarais said. “Camera traps show us that, on average, every scrape is visited by 12 bucks, each of which may or may not have CWD.”

CWD is a contagious, fatal, neurological disease that affects deer, including white-tailed deer, mule deer, elk, moose and caribou. It causes a spongy degeneration of the infected animal’s brain and weight loss, the reason for the term “wasting” disease.

Research has shown that infectious prions can remain in the environment for many years.

Currently, the primary way of diagnosing CWD is testing a deceased deer’s lymph nodes, an expensive and labor-intensive method that may not identify where the disease is located until the prevalence is too great to be impacted through management actions.

Demarais said the research should detect CWD “sparks,” or diseased deer that travel to areas without CWD.

“We wanted to see if we could use scrapes as a sentinel, an early warning signal that did not require sampling an individual deer,” Demarais said. “If one of those 12 bucks visiting a scrape is positive for CWD, we can detect CWD in an area even if no positive deer have been submitted by hunters.”

“Our success in detecting CWD prion contamination in scrapes shows that sampling has potential as a new tool for CWD surveillance, which can better detect disease in new areas through grouping samples compared to testing individuals,” Demarais continued. “For example, we found CWD prion contamination in scrapes tested in Mississippi wildlife management areas up to 19 miles from the nearest positive deer detection.”

The University of Minnesota and the MSU Veterinary Research and Diagnostic Lab are partnering with the Deer Lab to develop tests to detect prions in the soil and on branches gathered during sampling.

Stuart Lichtenberg, a researcher at the University of Minnesota and the Minnesota Center for Prion Research and Outreach, leads the laboratory analysis of scrape samples.

Lichtenberg said, this research is important because the traditional method of testing harvested deer paints an incomplete and delayed picture of CWD presence.

Rather than relying on an individual deer with CWD being harvested and submitted for testing, scrapes provide a collective sample from a dozen deer.

“It can take years for an animal to show symptoms of CWD. Even before that happens, animals can spread the disease and deposit prions into the environment. Because of this, early detection is critical for management decision making,” Lichtenberg said.

Demarais said scrape sampling results won’t cause an area to be entered into an agency’s CWD Management Zone, but positive results inform local hunters they may want to seriously consider testing harvested deer before bringing venison home to feed their family.

The research is funded by the U.S. Department of Agriculture’s Animal and Plant Health Inspection Service Wildlife Services and the Mississippi Department of Wildlife, Fisheries and Parks.

For more information on the MSU Deer Lab, a unit in the university’s Forest and Wildlife Research Center and MSU Extension Center, visit

For more on the Forest and Wildlife Research Center, visit